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Transmission utilities routinely collect detailed outage data, including resilience events in which outages bunch due to weather. The resilience events and associated metrics can readily be extracted from this historical outage data. Improvements such as asset hardening or investments in restoration lead to reduced outages or faster restoration. In this paper, we show how to rerun the historical events including the effects of the reduced outages or faster restorations to measure the resulting improvement in resilience metrics, thus quantifying the benefits of these investments. This is demonstrated with case studies for specific events (a derecho and a hurricane), and all large events or large thunderstorms in the Midwest USA. Instead of predicting future extreme events with models, which is very challenging, rerunning historical events readily quantifies the benefits of resilience investments if these investments had been made in the past. Rerunning historical events is particularly vivid in making the case for resilience investments as it quantifies the benefits for events actually experienced, rather than for uncertain future events. 

Abstract The human brain utilizes ∼20% of all of the body's metabolic resources, while chimpanzee brains use <10%. Although previous work shows significant differences in metabolic gene expression between the brains of primates, we have yet to fully resolve the contribution of distinct brain cell types. To investigate cell type–specific interspecies differences in brain gene expression, we conducted RNA-seq on neural progenitor cells, neurons, and astrocytes generated from induced pluripotent stem cells from humans and chimpanzees. Interspecies differential expression analyses revealed that twice as many genes exhibit differential expression in astrocytes (12.2% of all genes expressed) than neurons (5.8%). Pathway enrichment analyses determined that astrocytes, rather than neurons, diverged in expression of glucose and lactate transmembrane transport, as well as pyruvate processing and oxidative phosphorylation. These findings suggest that astrocytes may have contributed significantly to the evolution of greater brain glucose metabolism with proximity to humans.